Date: Wednesday, 11 October 2006, 6:30 PM
Location: SAP LABS, Building D, 3410 Hillview Avenue,
Palo Alto, CA (Google
Maps | Yahoo!
Maps | Mapquest)
Cost: Free and open to all who wish to attend, but membership is
only $10/year.
Topic
The past 10 years have led to a variety of measurements tools in molecular biology that are nearly-comprehensive in nature. For example, microarrays are just one of at least 30 large-scale measurement or experimental modalities available to investigators in molecular biology. Instead of focusing on the cell, or the genotype, or on any single measurement modality, using integrative biology allows us to think holistically and horizontally. We have been studying the process of intersecting nearly-comprehensive data sets in molecular biology, such as microarrays, RNAi and quantitative trait loci. Though standards are increasingly being required and used for microarray data, representing the experimental context using a structured vocabulary has not yet happened. I will show how the largest unified biomedical ontology can now be used to represent microarray sample annotations and show examples of visualization, searching, and analysis using this coding that could not have been done before. Attendees will learn about how to perform inferential processes across data sets, and will see an example of how we have used integrative biology to study the physiological process of fat storage.
About the Speaker
Atul Butte, M.D., Ph.D.
is an Assistant Professor in Medicine (Medical Informatics) and Pediatrics
at the Stanford University School of Medicine, and a board-certified pediatric
endocrinologist. Dr. Butte received his undergraduate degree in Computer
Science from Brown University in 1991, and worked in several stints as
a software engineer at Apple Computer (on the System 7 team) and Microsoft
Corporation (on the Excel team). He graduated from the Brown University
School of Medicine in 1995, during which he worked as a research fellow
at NIDDK through the Howard Hughes/NIH Research Scholars Program. He completed
his residency in Pediatrics and Fellowship in Pediatric Endocrinology in
2001, both at Children's Hospital, Boston. Dr. Butte received a Ph.D. in
Health Sciences and Technology from the Medical Engineering / Medical Physics
Program in the Division of Health Sciences and Technology, at Harvard Medical
School and Massachusetts Institute of Technology.
Dr. Butte's laboratory focuses on solving problems relevant to genomic
medicine by developing new biomedical-informatics methodologies in integrative
biology. Dr. Butte has authored more than 25 publications in bioinformatics,
medical informatics, and molecular diabetes and has delivered more than
30 presentations world-wide on bioinformatics, including nine at the National
Institutes of Health or NIH-sponsored meetings. Dr. Butte's recent awards
include the 2006 PhRMA Foundation Research Starter Grant in Informatics,
the 2003 Emory University School of Medicine Pathology Residents' Choice
Award, the 2002 and 2003 American Association for Clinical Chemistry Outstanding
Speaker Award, the 2002 Endocrine Society Travel Award based on presentation
merit, the 2001 American Association for Cancer Research Scholar-In-Training
Award and the 2001 Lawson Wilkins Pediatric Endocrine Society Clinical
Scholar Award. Dr. Butte's research is supported by grants from NIDDK and
NLM. Along with Isaac Kohane and Alvin Kho, Dr. Butte has co-authored one
of the first books on microarray analysis titled Microarrays
for an Integrative Genomics published by MIT Press.
News and Upcoming Events